![]() DMT is tryptamine with two methyl groups added to nitrogen. Hallucinogenic serotonin analogs. Tryptamine is serotonin minus the hydroxyl group, but this changes its properties significantly, giving it (and many other tryptamine derivatives) hallucinogenic properties. When we look at the chemical structure of 5-OMe DMT and some of its chemical cousins, it becomes clear why the drug impacts the brain – its similarity to serotonin.įigure 1. As a serotonin, aka 5-HT, analog, it is not surprising that 5-OMe DMT elicits a wide variety of physiological responses, including depression, nausea, rapid heart rate, and hallucinations – the reason frog lickers do their thing. 5-OMe DMT isn't licked for no reason the drug rapidly makes its way to the brain (4), where it binds (primarily) to the 5-HT2A subtype, one of the 15 known serotonin receptors. If only by accident, frog lickers need to get some credit for their pharmacological and neurochemical acumen. Images: Px Here, National Forest Service. The appearance of the Sonoran desert toad at different hours. The DEA 2010 Federal Register report classifying 5-OMeDMT as Schedule I (3) states that "there has been one death attributed to 5-OMe-DMT." This is roughly equivalent to the number of people who die every year from a coconut falling on their head, something I wrote about in 2018. ![]() Let's just say that the NPA may be exaggerating a bit. Licking or swallowing can lead to numbness of the mouth and throat as well as severe and life-threatening effects on the heart as a result of the digoxin-like compounds and catecholamines.ĭisturbingly, according to the NPS, smoking the stuff has recently become popular among certain celebrities, including Mike Tyson, who apparently "can't get enough of it."(Just a thought - can there be a more frightening image than Mike Tyson in a hallucinogenic state?) Although it is not a new practice (1), for some reason or other, the National Forest Service just issued an alert on its Facebook page warning people to knock it off because this attractive little fellow on the left, the Sonoran desert toad (aka Colorado river toad), has a rather profound defense system (2) that consists of a very powerful and potentially dangerous hallucinogen called 5-methoxy-N, N-dimethyltryptamine, aka 5-OMe-DMT. Like there aren't enough ways to get yourself high? Yet, that isn't stopping certain people who need a little extra kick–frog licking (no joke). ![]()
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